A new class of non-racemic chiral macrocycles: a conformational and synthetic study.

نویسندگان

  • Susan E Gibson
  • Nello Mainolfi
  • S Barret Kalindjian
  • Paul T Wright
  • Andrew J P White
چکیده

Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions.

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عنوان ژورنال:
  • Chemistry

دوره 11 1  شماره 

صفحات  -

تاریخ انتشار 2004