A new class of non-racemic chiral macrocycles: a conformational and synthetic study.
نویسندگان
چکیده
Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1,1-dimethylvalinol revealed that carboxylic acids generate acylals under reaction conditions often used for Heck reactions.
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عنوان ژورنال:
- Chemistry
دوره 11 1 شماره
صفحات -
تاریخ انتشار 2004